Opportunity Information: Apply for PAR 25 353

This funding opportunity supports research aimed at discovering and developing new treatments for mental disorders, substance use disorders (SUDs), and alcohol use disorder (AUD). It encourages collaboration between academia and industry to advance drug and neurostimulation approaches, with a focus on preclinical development and proof-of-concept testing. The program also seeks to develop novel ligands and circuit-engagement devices to explore and validate drug and device targets.

The grant funds multidisciplinary, long-term research initiatives involving multiple projects with a shared overarching goal. Those looking to support a more narrowly defined research effort should consider the companion U01 funding opportunity.

A wide range of institutions are eligible to apply, including federally recognized minority-serving institutions, faith-based organizations, tribal governments, regional organizations, and certain U.S.-affiliated entities. However, foreign organizations and non-domestic components of U.S. institutions are not eligible to apply, though foreign components may be included in applications.

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19 Clinical Trial Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
  • This funding opportunity was created on 2025-01-15.
  • Applicants must submit their applications by 2027-10-25.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Previous opportunity: Method to Extend Research in Time (MERIT) Award Extension Request (Type 4 eSubmission Clinical Trial Optional)

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